Methylation plays a role in gene expression. Methylation abnormalities have been linked to cancer, birth defects, lupus, muscular dystrophy, and other diseases. However, just as sufficient methylation is good for you, too much can be bad for you. Everything needs balance.
B vitamins contribute to methylation. It is one of their main functions. Limited research has been done on methylated vitamin B supplementation. Some studies show that the non-methylated forms of some B vitamin supplements are actually absorbed better by the body, and other studies show no significant difference. Ixcela will not offer methylated vitamins until peer-reviewed academic research indicates that these forms are better.
Diet is believed to be the best and most effective way of getting the methylated forms of vitamins. Leafy greens, legumes, asparagus, avocado, broccoli, and brussels sprouts can help to improve the methylation cycle. Making sure vitamin D and magnesium levels are normal is also helpful.