Our health profile questionnaire does not include gene mutation questions. The MTHFR (methylenetetrahydrofolate reductase) mutation can cause problems with the conversion of homocysteine to methionine. Ixcela does not measure homocysteine. Hyperhomocysteinemia can cause deficiencies in B12, B6, and folic acid. A deficiency of these vitamins has the potential to affect some of the metabolites we measure, especially serotonin and kynurenine. If you know you have this gene mutation, testing your serotonin and kynurenine levels is beneficial because both of these metabolites have the potential to affect quality of life.