Both NAC and CoQ10 are strong antioxidants. The body produces CoQ10 naturally (although this production decreases as we age), but NAC must be produced from other amino acids within the body, meaning it is conditionally essential. The body uses NAC to produce glutathione, a compound that combats free radicals and reduces inflammation in the body. Both NAC and CoQ10 effectively inhibit oxidative stress in the body. The primary difference is that NAC works by detoxifying the liver and kidneys (although it does offer neuroprotective benefits as well). CoQ10 plays a role in energy metabolism and ATP production, and it supports cardiovascular and brain health.