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What is the MTHFR mutation’s relationship to B vitamins and methylation?

MTHFR is an enzyme that is responsible for the methylation process, which is used by the body for a variety of processes including the utilization of certain B vitamins. Because of this mutation, clients with the MTHFR mutation may not be able to properly process B vitamins, especially folate. These clients may also experience high homocysteine, which is a risk factor for certain medical conditions. 


L-methionine and N-acetyl L-cysteine (NAC) might be helpful for clients who have methylation issues. The supplement SAMe may be beneficial as well. Certain dietary changes may also increase the potential for better methylation. For example, consuming leafy greens, legumes, asparagus, avocado, broccoli, and brussels sprouts can help to improve the methylation cycle. Making sure vitamin D and magnesium levels are normal is also helpful.